Title:Additive manufacturing of a multiplexed impedimetric biosensing system: laser-boosted nanolithography for targeted bacteria detection
Project PI: Prof. Jacek Ryl
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Collaboration: University of Lodz (PL), CEA (FR)
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Project PI: Dr. Marta Prześniak-Welenc
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Title: Thermoresponsive natural hydrogels in water/deep eutectic solvent systems as carriers for controlled-release of the antibiotics
Project PI: Dr. Tomasz Swebocki
Summary: The aim of this project is to develop controlled antibiotic delivery systems using biohydrogels, employing deep eutectic solvents (DESs). Combining DESs with naturally occurring hydrogels aims to improve control over drug release, increase the effectiveness of treating bacterial infections, and reduce the risk of antibiotic resistance while simultaneously ensuring sustainable development goals are met. This project aligns with one branch of the broader “One Health” policy, which focuses on combating the growing problem of antimicrobial resistance through the development of modern biomedical materials for treating wounds and infections.
Collaboration: University of Lodz (PL), CEA (FR)
Title: Hairy Solutions for “Micro” Problems – Polymer-Modified High-Exposure Antimicrobial Surfaces as a Neoteric Approach in Combating Antimicrobial Resistance
Project beneficiary: Dr. Tomasz Swebocki
Summary: The project aims to develop High-Exposure Antimicrobial Surfaces (HEASs) that prevent bacterial adhesion and biofilm formation through tailored surface chemistry and nanostructure. By combining conductive, high-surface-area materials such as glassy carbon and laser-induced graphene with selective antibacterial agents, the surfaces will actively resist fouling and enable real-time electrochemical monitoring of microbial activity. Electrochemical impedance spectroscopy will be used to track bacterial attachment and biofilm development, while microbiological tests will validate antimicrobial efficiency. The resulting materials are expected to show long-term stability, self-cleaning behavior, and selective bacterial inhibition, offering a sustainable route to reduce infections and combat antimicrobial resistance in biomedical and environmental settings.
Collaboration: University of Gdańsk (PL), Univeristy of Lodz (PL)
Title: Bioactivity design of the next generation of 3D printed glasses and glass composites
Project PI: Prof. Natalia Wójcik
Summary: The aim of the project was to design new compositions of bioactive glasses and glass-ceramic composites manufactured using 3D printing technology. Glass materials based on borates and phosphates had strong potential to compete with commonly used silicate-based biomaterials. Potassium, magnesium, zirconium, zinc, silver, and niobium were additionally introduced into materials containing significant amounts of calcium and sodium in order to tailor their in vitro dissolution process and improve their thermal stability and mechanical properties. Furthermore, a controlled nano- and micro-crystallization process of the parent glass was carried out to significantly influence the dissolution rate. The objective of this project was to select the most promising compositions and to use 3D printing technology to prepare scaffolds suitable for further biological testing.
Title: Niobium and nitrogen containing bioactive glasses and glass-ceramics for bone-implant applications
Project PI: Prof. Natalia Wójcik
Summary: The aim of this project was to develop novel and innovative compositions of bioactive glasses and glass-ceramics containing niobium and nitrogen, which would be competitive with commonly used biomaterials. The novel materials comprised phosphorus and calcium, which are the main building elements of bones. Additionally, sodium, an important element for the water-mineral balance in the human body, and magnesium, which also naturally occurs in the human body, were added to the glass network. Non-toxic niobium and nitrogen were incorporated to improve the stability and chemical durability of the materials. The objective of this work was also to characterize the fundamental as well as the critical biological properties of these materials. Moreover, the feasibility of these materials for potential bone replacement applications was validated.